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Ricardo Cerolini
Ricardo Cerolini

Clsi M45 A2 Pdf Download14


Clsi M45 A2 Pdf Download14




Clsi M45 A2 is a document that provides guidelines for antimicrobial susceptibility testing of infrequently isolated or fastidious bacteria. These are bacteria that are not commonly encountered in clinical microbiology laboratories or require special conditions for growth and testing. The document covers the selection of antimicrobial agents, the interpretation of test results, and the quality control procedures for these bacteria.


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The document was published by the Clinical and Laboratory Standards Institute (CLSI), a not-for-profit organization that develops and implements standards and guidelines for laboratory medicine. The document is based on the consensus of experts from various fields, such as microbiology, infectious diseases, pharmacology, and epidemiology. The document is intended for global application and is updated periodically to reflect the latest scientific evidence and clinical practice.


The document is available in PDF format and can be downloaded from the CLSI website [here]. Alternatively, you can access the document from other sources, such as [ResearchGate] or [Goums.ac.ir]. However, you may need to register or pay a fee to access these sources. The document is 184 pages long and contains 11 tables and 4 appendices. The document is divided into four main sections:



  • Introduction: This section provides the background, scope, and purpose of the document. It also explains the terminology, abbreviations, and symbols used in the document.



  • Methods: This section describes the methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria. It covers the preparation of media, inoculum, antimicrobial agents, and test devices. It also provides the procedures for performing and reading the tests.



  • Interpretive Criteria: This section presents the interpretive criteria for each bacterial species and antimicrobial agent combination. It also provides comments and recommendations for some specific situations.



  • Quality Control: This section outlines the quality control requirements for antimicrobial susceptibility testing of infrequently isolated or fastidious bacteria. It specifies the quality control strains, frequency of testing, acceptance criteria, and corrective actions.




The document also includes four appendices that provide additional information on topics such as disk diffusion zone diameter interpretive criteria, disk content tables, reference strains, and references.


Clsi M45 A2 is a valuable resource for clinical microbiology laboratories that encounter infrequently isolated or fastidious bacteria. It helps to ensure the accuracy, reliability, and comparability of antimicrobial susceptibility testing results. It also supports the optimal use of antimicrobial agents and the prevention of antimicrobial resistance.


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